Allergy test - Oral Challenge

Skin prick tests and specific IgE blood tests are often used to aid in the diagnosis of food allergies. However, having positive skin tests or specific IgE to foods does not necessarily mean that the patient is allergic to those foods. The reason is because the body can develop an immune response called oral tolerance that suppresses the food allergy while the skin or blood test remains positive. Therefore, young children with food allergies often develop tolerance when they grow older while their test results remain positive for a few more years. On the other hand, negative skin or blood tests can reliably exclude immediate-type food allergy.

Allergists therefore use food challenge to determine whether a patient is allergic to a particular food when there is suspicion that skin or blood test results are incorrect, or when the patient might have outgrown his/her food allergy. An open challenge is performed by simply giving the patient increasing amounts of the food under close medical supervision. However, a significant amount of psychological overlay is sometimes present, which will bias the result of the challenge. Therefore the food is often hidden in a vehicle such as apple sauce and given to the patient in a single-blinded (subject is blinded to the test condition) or double-blinded (both observer and subject blinded) manner, alternating with plain vehicle.

Reference information:  www.allergy.hk

The information aims to provide educational purpose only. Anyone reading it should consult physician before considering treatment and should not rely on the information above.

Eczema and dermatitis

Eczema and dermatitis are terms that mean skin inflammation. The two most common types of dermatitis are atopic dermatitis and contact dermatitis. Whereas the two types of dermatitis are indistinguishable pathologically, there are differences in terms of epidemiology, etiology and treatment.

Atopic dermatitis usually starts in infancy or early childhood. The basic problem with atopic dermatitis is an inborn defect in skin barrier function. The skin is an important barrier that protects us from our environment, and normally does not allow allergens to penetrate through. Genetic defects that lead to a reduction in the barrier function allow substances to penetrate the skin more easily. The defects also increase water loss from the skin, and dry skin is a characteristic of this condition. 

Allergens that penetrate through the skin barrier interact with Langerhan cells within the skin, which direct the immune system to develop allergic sensitivity to these substances. Infants with eczema are therefore much more likely to develop food allergy, respiratory allergy and asthma.


Eczema therefore predisposes an individual to developing allergies and not the other way around as previously thought. Once the patient develops allergic sensitivity to an allergen, exposure to that allergen through direct contact or ingestion then leads to allergic inflammation in the skin. Inflamed skin is dry, intensely itchy, rough and can become infected easily. Common allergens that can cause atopic dermatitis include food, house dust mites, chemical substances found in skin care products, rubber chemicals, metals, and even sweat and bacteria that live on the skin.

Reference information:  http://www.allergy.hk

The information aims to provide educational purpose only. Anyone reading it should consult physician before considering treatment and should not rely on the information above.