Food
allergy is consistently one of the most anxiety-provoking illnesses for
patients or their caregivers, especially if the problem is life-threatening.
Eating is something we do several times a day, and the fear that danger lurks
within every bite can seriously affect one’s mental well-being. Whereas
desensitization treatment has been used for the treatment of allergic rhinitis and asthma for many decades, previous attempts to develop vaccines for food
allergy have ended in failure.
In the last two years, several studies of oral peanut desensitization have been
published. While the majority of patients could be successfully desensitized,
this treatment is limited by the high rate of adverse reactions and the need
for close monitoring.
Sublingual desensitization is a new method of administering desensitization
treatment for patients suffering from house dust mite and pollen allergies. Recent
studies have shown effectiveness for patients suffering from allergic rhinitis and asthma. The advantages of this form of
treatment include convenience and safety.
A recent study of sublingual desensitization
for peanut allergy shows encouraging results. The study was carried out at Duke
University in North Carolina and Massachusetts General Hospital in Boston.
Eighteen children were given sublingual drops of a peanut allergen extract or
placebo at increasing doses. None of the patients suffered severe adverse
reactions, with only oral itching as the most significant side effect.
After 12
months of treatment, those who took the extract could tolerate 20 times the
amount of peanut given in an oral challenge than those who took placebo. The
average amount tolerated was 1700mg, which was equivalent to 6 – 7 peanuts.
Presumably, these patients could continue to eat peanuts regularly to maintain
their desensitized state thereafter.
We have started to perform sublingual peanut desensitization using the same
extract recently and several patients have been successfully desensitized. We
are hopeful that this would become a viable alternative for the majority of
patients suffering from peanut allergy.
The information aims to provide educational purpose only. Anyone reading
it should consult physician before considering treatment and should not rely on the information above.